AKI secondary to ?viral infection /NSAID abuse



A 45 yr old female who is farmer by occupation.,with h/o B/L knee pains (? Osteoarthritis) taken injections for pain relief by RMP for every 2-3 days since 1yr .no h/o small joint pains or early morning stiffness 
 She was apparently asymptomatic 1 1/2 month back -had fever,  which lasted for 6days, low grade intermittent -pt had taken T. Dolo 650mg TID for 3days following which pt became hypoactive (drowsy but arousable)  -was taken to hospital on 11/8/21  where  routine investigations done, showed plt count of 7000 (for which 1 SDP transfusion was done)  with denovo HTN(170/90) and DM 2 (GRBS-233)  and managed conservatively -diagnosed as MODS WITH AKI WITH ENCEPHALOPATHY  as pt had become disoriented to  place then DIALYSIS was initiated (then her cr 4,4 urea-181) and repeted every 2 days 
No h/o recurrent oral ulcers, joint pains 

Past history : 6 months back surgery for renal stones, hysterectomy 

Personal history :
Loss of appetite
Mixed diet
B&B -regular and normal
No known allergies 
No addictions 

 On examination :
No pallor, cyanosis, clubbing, generalised lymphadenopathy
ANASARCA+
her vitals are
PR-116bpm
BP-170/90
RR-22cpm
Spo2- 92
Grbs-170mg%


SYSTEMIC EXAMINATION :
cvs: s1 s 2 heard 
R/s: bae+ nvbs heard
P/A: distended abdomen, bowel sounds heard
Cns: pt is conscious
Speech -normal
No signs of meningeal irritation 
Cranial nerves examination - normal
Motor, sensory system examination -normal
GCS -15/15 

PROVISIONAL DIAGNOSIS :

AKI SECONDARY TO ?viral infection /NSAID ABUSE with k,/c/o HTN and DM-ll

Investigations:
Outside the hospital:
OPHTHALMOLOGY OPINION:
On 6/9/21:
24 hr URINARY volume -1500ml
24 hr URINARY Protein-236mg/day
24 hr URINARY creatinine-0.6g/day
on 7/9/21
NEPHROLOGY OPINION:
On 8/9/21:
On 9/9/21:
Combs test:
DCT- POSITIVE
ICT-NEGATIVE 
ORTHO OPINION:
DERMATOLOGIST  OPINION :
On 11/9/21:





Treatment:
Salt restriction lessthan 2.4g per day 
Fluid restriction lessthan 1.5 l/day
Inj Lasix 40 mg iv/bd
Inj Ceftriaxone 1gm IV/bd 
Inj. PANTOP 40mg IV/od 
Inj.zofer 4mg IV/sos 
Inj Neomol 100 ML NS IV/sos
T.Pcm 500 mg po/bd 
T.orofer xT  po/od 
Bp/PR/TEMP/RR  CHARTING 4TH HRLY 
Grbs charting 6th hrly 
Inj HAI  s/c acc to sliding scale 
I/o charting 
T.cilnidipine 5 mg od
T.Arkamine 0.1 mg po/od 

On 5/9/21:
S-
Vomitings of 2episodes since yesterday 
Stools not passed 
O-
Pt is c/c/c
Afebrile 
BP-190/100 mmHg
PR -120bpm
Spo2-96 %on RA 
RR-21cpm 
Grbs-134
I/o-900/550
CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS heard 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj Ceftriaxone 1gm IV/bd 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj pantop 40 mg iv/od
Inj zofer 4mg IV/sos 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
Inj.HAI s/c acc to sliding scale 
Inform Grbs 
Strict i/o charting 

On 6/9/21:

S-
No fresh complaints 
Vomitings subsided 
Decreased appetite 
Stools not passed 
O-
Pt is c/c/c
Afebrile 
BP-160/190 mmHg
PR -106bpm
Spo2-96 %on RA 
RR-21cpm 
Grbs-112mg/dl
I/o-900/550
CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS heard 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj Ceftriaxone 1gm IV/bd 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj pantop 40 mg iv/od
Inj zofer 4mg IV/sos 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
Inj.HAI s/c acc to sliding scale 
Inform Grbs 
Strict i/o charting 
Syp.cremaffin plus po/hs

On 7/9/21:

S-
No fresh complaints 
Stools not passed
O-
Pt is c/c/c
Afebrile 
BP-170/190 mmHg
PR -98bpm
Spo2-98 %on RA 
RR-20cpm 
Grbs-186
I/o-1300/1150
CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS heard ,decreased breath sounds in b/l IAA,ISA 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj Ceftriaxone 1gm IV/bd 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj pantop 40 mg iv/od
Inj zofer 4mg IV/sos 
T.Metformin 500 mg po/od 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
T.Aldactone 25mg po/od
2-3egg whites /day
Grbs -6th hrly 
Monitor vitals 4th hrly 
Strict i/o charting 
Protein powder-D (sugar free) 2 spoons in  one glass of milk -bd

On 8/9/21:

S-
No fresh complaints 
Stools not passed
O-
Pt is c/c/c
Afebrile 
BP-130/80mmHg
PR -86bpm 
Spo2-98 %on RA 
RR-22cpm 

CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS heard ,decreased breath sounds in b/l IAA,ISA 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj Ceftriaxone 1gm IV/bd 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj pantop 40 mg iv/od
Inj zofer 4mg IV/sos 
T.Metformin 500 mg po/od 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
T.Aldactone 25mg po/od
2-3egg whites /day
Grbs -6th hrly 
Monitor vitals 4th hrly 
Strict i/o charting 
Protein powder-D (sugar free) 2 spoons in  one glass of milk -bd

On 9/9/21:
S-
No fresh complaints 
Stools not passed
O-
Pt is c/c/c
Afebrile 
BP-150/60 mmHg
PR -88bpm
Spo2-98 %on RA 

CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS  heard 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj zofer 4mg IV/sos 
T.Metformin 500 mg po/od 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
T.Aldactone 25mg po/od
2-3egg whites /day
Grbs -6th hrly 
Monitor vitals 4th hrly 
Strict i/o charting 
Protein powder-D (sugar free) 2 spoons in  one glass of milk -bd

On 10/9/21:

S-
No fresh complaints 
Stools not passed 
O-
Pt is c/c/c
Afebrile 
BP-140/80 mmHg
PR -84bpm
Spo2-98 %on RA 

CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS  heard 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj zofer 4mg IV/sos 
T.Metformin 500 mg po/od 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
T.Aldactone 25mg po/od
2-3egg whites /day
Grbs -6th hrly 
Monitor vitals 4th hrly 
Strict i/o charting 
Protein powder-D (sugar free) 2 spoons in  one glass of milk -bd

On 11/9/21:
S-
No fresh complaints 
Stools passed yesterday night
O-
Pt is c/c/c
Afebrile 
BP-140/80 mmHg
PR -82bpm
Spo2-98 %on RA 

CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS  heard 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj zofer 4mg IV/sos 
T.Metformin 500 mg po/od 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
T.Aldactone 25mg po/od
2-3egg whites /day
Grbs -6th hrly 
Monitor vitals 4th hrly 
Strict i/o charting 
Protein powder-D (sugar free) 2 spoons in  one glass of milk -bd

On 12/9/21:

S-
No fresh complaints 
Stools not passed
O-
Pt is c/c/c
Afebrile 
BP- mmHg
PR -bpm
Spo2-98 %on RA 

CVS- s1 s2 heard 
Cns- NAD 
R/s- NVBS  heard 
P/A- soft 

A-
AKI SECONDARY TO?viral infection/NSAID ABUSE with k/c/o HTN and DM-ll 
P-
Fluid restriction lessthan 1l per day 
SALTRESTRICTION  lessthan 2.4g per day 
Inj lasix iv/tid(60mg-60mg-40 mg)
Inj zofer 4mg IV/sos 
T.Metformin 500 mg po/od 
T.CINOD 10mg po/bd 
T.Arkamine 0.1 mg po/bd
T.Nodosis 500mg po/bd
T.orofer xT po/od
T.Pcm 500mg po/sos
T.Aldactone 25mg po/od
2-3egg whites /day
Grbs -6th hrly 
Monitor vitals 4th hrly 
Strict i/o charting 
Protein powder-D (sugar free) 2 spoons in  one glass of milk -bd




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